FAQ
Collagen is a protein found in your body that is used to make connective tissue. It is the primary building block of your body’s skin, muscles, bones, tendons, ligaments, and other connective tissues. It’s also found in your organs, blood vessels and intestinal lining.
Collagen is a protein found in your body that is used to make connective tissue. It is the primary building block of your body’s skin, muscles, bones, tendons, ligaments, and other connective tissues. It’s also found in your organs, blood vessels and intestinal lining.
Your body produces less collagen as you age, and existing collagen breaks down at a faster rate. The collagen is also lower in quality than when you were younger. Women experience a significant reduction in collagen production after menopause.
Your body produces less collagen as you age, and existing collagen breaks down at a faster rate. The collagen is also lower in quality than when you were younger. Women experience a significant reduction in collagen production after menopause.
Collagen can’t be measured — for instance, in a blood test — but there are signs that your collagen level is decreasing – wrinkled skin, hallowing in and around your eyes and face, weakening muscles, stiffer, less flexible tendons and ligaments, joint pain or osteoarthritis and more.
Collagen can’t be measured — for instance, in a blood test — but there are signs that your collagen level is decreasing – wrinkled skin, hallowing in and around your eyes and face, weakening muscles, stiffer, less flexible tendons and ligaments, joint pain or osteoarthritis and more.
Collagen in foods can’t be absorbed by your body in its whole form. Your body breaks down the collagen proteins you eat into amino acids. So eating collagen-rich foods doesn’t directly result in higher collagen levels in your body.
Collagen in foods can’t be absorbed by your body in its whole form. Your body breaks down the collagen proteins you eat into amino acids. So eating collagen-rich foods doesn’t directly result in higher collagen levels in your body.
Collagen first appeared as an ingredient in skin creams and serums. However, its effectiveness as a topical application was doubted even by dermatologists, as collagen is not naturally found on the skin’s surface but in the deeper layers. Applied topically, collagen fibers are too large to permeate the skin’s outer layers. This is why oral collagen peptides supplements in the form of pills or powders are believed to be more effectively absorbed by the body.
Collagen first appeared as an ingredient in skin creams and serums. However, its effectiveness as a topical application was doubted even by dermatologists, as collagen is not naturally found on the skin’s surface but in the deeper layers. Applied topically, collagen fibers are too large to permeate the skin’s outer layers. This is why oral collagen peptides supplements in the form of pills or powders are believed to be more effectively absorbed by the body.
Collagen peptides are small pieces of animal collagen. Collagen can’t be absorbed in a whole form and it has to be broken down into smaller pieces called peptides. Collagen peptides are absorbed through your gastrointestinal tract, then released in the blood and eventually reach the skin and other organs.
Collagen peptides are small pieces of animal collagen. Collagen can’t be absorbed in a whole form and it has to be broken down into smaller pieces called peptides. Collagen peptides are absorbed through your gastrointestinal tract, then released in the blood and eventually reach the skin and other organs.
Yes. Some research on collagen supplements is related to skin, nails, joints health as well as overall body composition and body strength. Randomized controlled trials have found that collagen supplements improve skin elasticity. Other trials have found that supplementing with collagen peptides can improve joint mobility and decrease joint pain such as with osteoarthritis or in athletes. More information can be found below.
Yes. Some research on collagen supplements is related to skin, nails, joints health as well as overall body composition and body strength. Randomized controlled trials have found that collagen supplements improve skin elasticity. Other trials have found that supplementing with collagen peptides can improve joint mobility and decrease joint pain such as with osteoarthritis or in athletes. More information can be found below.
Some research shows that collagen peptide supplementation in combination with resistance training improved body composition and increased muscle strength. Resistance training alone has proven to do that, but the studies suggested that the effect is better pronounced in those who supplemented with collagen peptides.
Some research shows that collagen peptide supplementation in combination with resistance training improved body composition and increased muscle strength. Resistance training alone has proven to do that, but the studies suggested that the effect is better pronounced in those who supplemented with collagen peptides.
Research & Clinical Trials
There is a number of studies on the effects of collagen and some of the findings are conflicting. However, not all studies are created equal. Some use a very small sample size of people and others are flawed for a variety of reasons. This is why in answering the questions above we referred to studies that used a larger sample size of people and were directed to answer the specific question of interest.
Collagen Peptides & Skin, joints health
Participants: healthy adults, age 35-60 years.
The objective of the study was to evaluate the impact of collagen peptides on the human skin. The participants were 100 healthy adults randomly assigned to receive a test product containing collagen peptides or a placebo (a substance that has no therapeutic effect). Parameters of skin wrinkles, elasticity, hydration, and whitening (melanin and erythema indexes) were measured at baseline and after 4, 8, and 12 weeks. Compared with the placebo group, the average skin roughness, maximum of all peak-to-valley values, maximum peak height of the wrinkle, and average maximum height of the wrinkle were significantly improved in the test group. Parameters of skin elasticity, including overall elasticity, net elasticity, and biological elasticity, were also significantly improved in the test group at Week 12 as compared with the placebo group. Skin hydration and whitening parameters changed more significantly in the test group than in the placebo group. None of the participants experienced adverse events related to the test product.
The full article can be found here:
https://pubmed.ncbi.nlm.nih.gov/37822045
Participants: healthy adults, age 35-60 years.
The objective of the study was to evaluate the impact of collagen peptides on the human skin. The participants were 100 healthy adults randomly assigned to receive a test product containing collagen peptides or a placebo (a substance that has no therapeutic effect). Parameters of skin wrinkles, elasticity, hydration, and whitening (melanin and erythema indexes) were measured at baseline and after 4, 8, and 12 weeks. Compared with the placebo group, the average skin roughness, maximum of all peak-to-valley values, maximum peak height of the wrinkle, and average maximum height of the wrinkle were significantly improved in the test group. Parameters of skin elasticity, including overall elasticity, net elasticity, and biological elasticity, were also significantly improved in the test group at Week 12 as compared with the placebo group. Skin hydration and whitening parameters changed more significantly in the test group than in the placebo group. None of the participants experienced adverse events related to the test product.
The full article can be found here:
https://pubmed.ncbi.nlm.nih.gov/37822045
Participants: female, age 35-55 years.
The objective of this research was to understand the effectiveness of collagen peptides on skin biophysical parameters related to cutaneous aging. In this clinical trial, 69 female ages 35-55 years received 2.5 grams or 5.0 grams of collagen peptides or placebo (a substance that has no therapeutic effect) once daily for 8 weeks, with 23 female being allocated to each treatment group. Skin elasticity, skin moisture, trans-epidermal water loss and skin roughness were objectively measured before the first oral product application and after 4 and 8 weeks of regular intake. Skin elasticity (primary interest) was also assessed at follow-up 4 weeks after the last intake of collagen peptides. At the end of the study, skin elasticity in both collagen peptides dosage groups showed a statistically significant improvement in comparison to placebo. After 4 weeks of follow-up treatment, a statistically significantly higher skin elasticity level was determined in elderly women. With regard to skin moisture and skin evaporation, a positive influence of collagen peptides treatment could be observed in a subgroup analysis, but the data failed to reach a level of statistical significance. No side effects were noted throughout the study.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/23949208/
Participants: female, age 35-55 years.
The objective of this research was to understand the effectiveness of collagen peptides on skin biophysical parameters related to cutaneous aging. In this clinical trial, 69 female ages 35-55 years received 2.5 grams or 5.0 grams of collagen peptides or placebo (a substance that has no therapeutic effect) once daily for 8 weeks, with 23 female being allocated to each treatment group. Skin elasticity, skin moisture, trans-epidermal water loss and skin roughness were objectively measured before the first oral product application and after 4 and 8 weeks of regular intake. Skin elasticity (primary interest) was also assessed at follow-up 4 weeks after the last intake of collagen peptides. At the end of the study, skin elasticity in both collagen peptides dosage groups showed a statistically significant improvement in comparison to placebo. After 4 weeks of follow-up treatment, a statistically significantly higher skin elasticity level was determined in elderly women. With regard to skin moisture and skin evaporation, a positive influence of collagen peptides treatment could be observed in a subgroup analysis, but the data failed to reach a level of statistical significance. No side effects were noted throughout the study.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/23949208/
Participants: young active adults.
The aim of the study was to evaluate the use of collagen peptides in reducing pain in athletes with functional knee problems during sport. One hundred thirty-nine athletes with functional knee pain ingested 5 grams of collagen peptides or a placebo (a substance that has no therapeutic effect) per day for 12 weeks. The primary outcome of the study was a change in pain intensity during activity, which was evaluated by the participants and the attending physicians using a visual analogue scale. As secondary endpoints, pain intensity under resting conditions, the range of motion of the knee joint, and the use of additional therapeutic options were assessed. The results revealed a statistically significant improvement in activity-related pain intensity in the group that was supplemented with collagen peptides compared with placebo. The results were confirmed by the physician’s assessment. Pain under resting conditions was also improved, but no significance compared with placebo was detected. Due to the high joint mobility at baseline, no significant changes of this parameter could be detected. The use of additional treatment options was significantly reduced after collagen peptides intake. The study demonstrated that the supplementation of collagen peptides in young adults with functional knee problems led to a statistically significant improvement of activity-related joint pain.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/28177710/
Participants: young active adults.
The aim of the study was to evaluate the use of collagen peptides in reducing pain in athletes with functional knee problems during sport. One hundred thirty-nine athletes with functional knee pain ingested 5 grams of collagen peptides or a placebo (a substance that has no therapeutic effect) per day for 12 weeks. The primary outcome of the study was a change in pain intensity during activity, which was evaluated by the participants and the attending physicians using a visual analogue scale. As secondary endpoints, pain intensity under resting conditions, the range of motion of the knee joint, and the use of additional therapeutic options were assessed. The results revealed a statistically significant improvement in activity-related pain intensity in the group that was supplemented with collagen peptides compared with placebo. The results were confirmed by the physician’s assessment. Pain under resting conditions was also improved, but no significance compared with placebo was detected. Due to the high joint mobility at baseline, no significant changes of this parameter could be detected. The use of additional treatment options was significantly reduced after collagen peptides intake. The study demonstrated that the supplementation of collagen peptides in young adults with functional knee problems led to a statistically significant improvement of activity-related joint pain.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/28177710/
Participants: adults, 18-30 years old.
The purpose of the study was to understand the efficacy of collagen peptides to reduce activity-related joint pain in young adults. In total, 180 active men and women aged between 18 and 30 years with exercise-related knee pain but no diagnosed joint disease completed the trial over a period of 12 weeks. Participants were randomly assigned to a group receiving 5 grams of collagen peptides or group that received placebo (a substance that has no therapeutic effect). For the primary outcome, changes in pain during or after exercise from pre- to post-intervention were assessed by the participants using the Visual Analog Scale. These changes were additionally evaluated by the examining physician by means of anamnesis and physical examination of the affected knee joint. As secondary outcomes, pain under resting conditions and after 20 squats were compared between the study groups. In addition, the mobility of the knee joint and the use of alternative therapies were recorded. The supplementation of collagen peptides led to a statistically significantly reduction of exercise-induced knee pain compared with the placebo group. These findings were consistent with the physician’s evaluation. The decrease in pain under resting conditions and after squats did not significantly differ between the groups, as only a small number of participants suffered from pain under these conditions. Due to the clinically unremarkable baseline values, the mobility of the knee joint did not change significantly after the intervention. In conclusion, the current investigation confirmed that the oral intake of bioactive collagen peptides used in the current investigation led to a statistically significant reduction of activity-related joint pain in young active adults suffering from knee joint discomfort.
The full article can be found here:
https://pubmed.ncbi.nlm.nih.gov/33562729/
Participants: adults, 18-30 years old.
The purpose of the study was to understand the efficacy of collagen peptides to reduce activity-related joint pain in young adults. In total, 180 active men and women aged between 18 and 30 years with exercise-related knee pain but no diagnosed joint disease completed the trial over a period of 12 weeks. Participants were randomly assigned to a group receiving 5 grams of collagen peptides or group that received placebo (a substance that has no therapeutic effect). For the primary outcome, changes in pain during or after exercise from pre- to post-intervention were assessed by the participants using the Visual Analog Scale. These changes were additionally evaluated by the examining physician by means of anamnesis and physical examination of the affected knee joint. As secondary outcomes, pain under resting conditions and after 20 squats were compared between the study groups. In addition, the mobility of the knee joint and the use of alternative therapies were recorded. The supplementation of collagen peptides led to a statistically significantly reduction of exercise-induced knee pain compared with the placebo group. These findings were consistent with the physician’s evaluation. The decrease in pain under resting conditions and after squats did not significantly differ between the groups, as only a small number of participants suffered from pain under these conditions. Due to the clinically unremarkable baseline values, the mobility of the knee joint did not change significantly after the intervention. In conclusion, the current investigation confirmed that the oral intake of bioactive collagen peptides used in the current investigation led to a statistically significant reduction of activity-related joint pain in young active adults suffering from knee joint discomfort.
The full article can be found here:
https://pubmed.ncbi.nlm.nih.gov/33562729/
Participants: adults.
*low sample size (25 participants).
The goal of this study was to investigate whether daily oral supplementation with collagen peptides alleviates the symptoms of brittle nails and improves nail growth rate. In this trial 25 participants took 2.5 g of specific bioactive collagen peptides once daily for 24 weeks followed by a 4-week off-therapy period. Nail growth rate and the frequency of cracked and/or chipped nails as well as an evaluation of symptoms and global clinical improvement score of brittle nails were assessed by a physician during treatment and 4 weeks after discontinuation. Bioactive collagen peptides treatment promoted an increase of 12% nail growth rate and a decrease of 42% in the frequency of broken nails. Additionally, 64% of participants achieved a global clinical improvement in brittle nails, and 88% of participants experienced an improvement 4 weeks post-treatment. The majority of participants (80%) agreed that the use of collagen peptides improved their nails' appearance, and were completely satisfied with the performance of the treatment.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/28786550/
Participants: adults.
*low sample size (25 participants).
The goal of this study was to investigate whether daily oral supplementation with collagen peptides alleviates the symptoms of brittle nails and improves nail growth rate. In this trial 25 participants took 2.5 g of specific bioactive collagen peptides once daily for 24 weeks followed by a 4-week off-therapy period. Nail growth rate and the frequency of cracked and/or chipped nails as well as an evaluation of symptoms and global clinical improvement score of brittle nails were assessed by a physician during treatment and 4 weeks after discontinuation. Bioactive collagen peptides treatment promoted an increase of 12% nail growth rate and a decrease of 42% in the frequency of broken nails. Additionally, 64% of participants achieved a global clinical improvement in brittle nails, and 88% of participants experienced an improvement 4 weeks post-treatment. The majority of participants (80%) agreed that the use of collagen peptides improved their nails' appearance, and were completely satisfied with the performance of the treatment.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/28786550/
Collagen Peptides & Body composition, muscle and tendon size & strength
Participants: Female.
One of the studies that speaks to this specific topic found that collagen peptides supplementation in combination with resistance training improved body composition and regional muscle strength in premenopausal women. In this clinical trial 77 premenopausal women completed a 12-week resistance training including 3 sessions per week. All participants were split in 2 groups. One of the groups was supplemented with 15 grams of collagen peptides per day and the other group was given placebo (a substance that has no therapeutic effect). Changes in body composition were determined by bioelectrical impedance analysis and muscular strength by isometric strength testing. Both groups showed statistically significant increases in fat free mass. The results for the group supplemented with collagen peptides were more pronounces. Similarly, the decline of body fat percentage was higher in the group that was supplemented with collagen peptides. The women receiving 15 grams of collagen peptides daily also showed a higher gain in hand-grip compared to those performing resistance training only.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/31010031/
Participants: Female.
One of the studies that speaks to this specific topic found that collagen peptides supplementation in combination with resistance training improved body composition and regional muscle strength in premenopausal women. In this clinical trial 77 premenopausal women completed a 12-week resistance training including 3 sessions per week. All participants were split in 2 groups. One of the groups was supplemented with 15 grams of collagen peptides per day and the other group was given placebo (a substance that has no therapeutic effect). Changes in body composition were determined by bioelectrical impedance analysis and muscular strength by isometric strength testing. Both groups showed statistically significant increases in fat free mass. The results for the group supplemented with collagen peptides were more pronounces. Similarly, the decline of body fat percentage was higher in the group that was supplemented with collagen peptides. The women receiving 15 grams of collagen peptides daily also showed a higher gain in hand-grip compared to those performing resistance training only.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/31010031/
Participants: Middle-age male, untrained.
Another study has shown that collagen peptides combined with resistance training improves body composition and muscle strength in middle-aged, untrained men. In the exploratory part of the study, these results were compared with another group that had received whey protein in addition to the resistance training. Ninety-seven men completed this study and participated in a 12-week resistance training program. All participants were split into 3 groups. The first group ingested 15 grams of collagen peptides per day, the second was given placebo (a substance that has no therapeutic effect) and the third ingested 15 grams of whey protein daily. Changes in fat free mass and fat mass were determined by dual-energy X-ray absorptiometry, and isometric leg strength was measured. All participants had statistically significantly improved levels in fat free mass, decreased fat mass and improved leg strength. The main analysis revealed a statistically significantly higher increase in fat free mass and decrease in fat mass in the group that was supplemented with collagen peptides compared with the placebo group.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/33946565/
Participants: Middle-age male, untrained.
Another study has shown that collagen peptides combined with resistance training improves body composition and muscle strength in middle-aged, untrained men. In the exploratory part of the study, these results were compared with another group that had received whey protein in addition to the resistance training. Ninety-seven men completed this study and participated in a 12-week resistance training program. All participants were split into 3 groups. The first group ingested 15 grams of collagen peptides per day, the second was given placebo (a substance that has no therapeutic effect) and the third ingested 15 grams of whey protein daily. Changes in fat free mass and fat mass were determined by dual-energy X-ray absorptiometry, and isometric leg strength was measured. All participants had statistically significantly improved levels in fat free mass, decreased fat mass and improved leg strength. The main analysis revealed a statistically significantly higher increase in fat free mass and decrease in fat mass in the group that was supplemented with collagen peptides compared with the placebo group.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/33946565/
Participants: Young male, recreationally active.
The study aimed to determine the effects of long-term collagen peptide supplementation in combination with resistance exercise training on body composition, strength, and muscle fiber cross-sectional area in recreationally active men. Fifty-seven young men were divided into a group receiving either 15 grams of collagen peptides per day or a placebo (a substance that has no therapeutic effect). Strength testing, bioimpedance analysis, and muscle biopsies were used prior to and after a resistance exercise training intervention. Food record protocols were performed during the study. The groups trained three times a week for 12 weeks. Baseline parameters showed no differences between groups, and the external training load and dietary food intake were also similar. The group taking collagen peptides showed a statistically significant increase in fat-free mass compared with the placebo group. Body fat mass was unchanged in the group taking collagen, whereas a significant increase in body fat mass was observed in the placebo group. Both groups showed significant increases in all strength tests, with a trend for a slightly more pronounced effect in group taking collagen.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/31126103/
Participants: Young male, recreationally active.
The study aimed to determine the effects of long-term collagen peptide supplementation in combination with resistance exercise training on body composition, strength, and muscle fiber cross-sectional area in recreationally active men. Fifty-seven young men were divided into a group receiving either 15 grams of collagen peptides per day or a placebo (a substance that has no therapeutic effect). Strength testing, bioimpedance analysis, and muscle biopsies were used prior to and after a resistance exercise training intervention. Food record protocols were performed during the study. The groups trained three times a week for 12 weeks. Baseline parameters showed no differences between groups, and the external training load and dietary food intake were also similar. The group taking collagen peptides showed a statistically significant increase in fat-free mass compared with the placebo group. Body fat mass was unchanged in the group taking collagen, whereas a significant increase in body fat mass was observed in the placebo group. Both groups showed significant increases in all strength tests, with a trend for a slightly more pronounced effect in group taking collagen.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/31126103/
Participants: elderly male.
This study found similar effects but this time the study was conducted with elderly men. The objective of this study was to assess the influence of post-exercise protein supplementation with collagen peptides v. placebo (a substance that has no therapeutic effect) on muscle mass and muscle function following resistance training in elderly people with sarcopenia (age-related progressive loss of muscle mass and strength). A total of fifty-three men with sarcopenia completed this randomized double-blind placebo-controlled study. All the participants underwent a 12-week guided resistance training program including three sessions per week. All participants were split in 2 groups. One of the groups was supplemented with 15 grams of collagen peptides per day and the other group was given placebo (a substance that has no therapeutic effect). Fat-free mass, fat mass and bone mass were measured before and after the intervention using dual-energy X-ray absorptiometry. Isokinetic quadriceps strength of the right leg was determined and sensory motor control was investigated by a standardized one-leg stabilization test. Following the training program, all the subjects showed statistically significantly higher levels of fat free mass, bone mass, isokinetic quadriceps strength and sensory motor control with statistically significantly lower levels for fat mass. The effect was significantly more pronounced in subjects receiving collagen peptides.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/26353786/
Participants: elderly male.
This study found similar effects but this time the study was conducted with elderly men. The objective of this study was to assess the influence of post-exercise protein supplementation with collagen peptides v. placebo (a substance that has no therapeutic effect) on muscle mass and muscle function following resistance training in elderly people with sarcopenia (age-related progressive loss of muscle mass and strength). A total of fifty-three men with sarcopenia completed this randomized double-blind placebo-controlled study. All the participants underwent a 12-week guided resistance training program including three sessions per week. All participants were split in 2 groups. One of the groups was supplemented with 15 grams of collagen peptides per day and the other group was given placebo (a substance that has no therapeutic effect). Fat-free mass, fat mass and bone mass were measured before and after the intervention using dual-energy X-ray absorptiometry. Isokinetic quadriceps strength of the right leg was determined and sensory motor control was investigated by a standardized one-leg stabilization test. Following the training program, all the subjects showed statistically significantly higher levels of fat free mass, bone mass, isokinetic quadriceps strength and sensory motor control with statistically significantly lower levels for fat mass. The effect was significantly more pronounced in subjects receiving collagen peptides.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/26353786/
Participants*: male, 22 – 30 years old.
*low sample size.
The purpose of this study was to investigate the effect of collagen peptides combined with resistance training on changes in tendinous and muscular properties. In this study 40 healthy male, 22 to 30 years old, were split in 2 groups. One group received a daily dosage of 5grams of collagen peptides while the other group received 5grams of a placebo (a substance that has no therapeutic effect). Both groups completed a 14 weeks high-load resistance training program. Changes in Achilles tendon cross-sectional area, tendon stiffness, muscular strength, and thickness of the plantar flexors were measured. The group that was supplemented with collagen peptides showed a significantly greater increase in tendon cross section area compared with the groups that was given placebo. Moreover, the statistical analysis revealed a significantly greater increase in muscle thickness in the collagen peptides group compared with the placebo group. Finally, tendon stiffness and muscle strength increased in both groups, with no statistical difference between the groups. In conclusion, the current study shows that the supplementation of collagen peptides combined with resistance training is associated with a greater hypertrophy in tendinous and muscular structures than resistance training alone.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/35403756/
Participants*: male, 22 – 30 years old.
*low sample size.
The purpose of this study was to investigate the effect of collagen peptides combined with resistance training on changes in tendinous and muscular properties. In this study 40 healthy male, 22 to 30 years old, were split in 2 groups. One group received a daily dosage of 5grams of collagen peptides while the other group received 5grams of a placebo (a substance that has no therapeutic effect). Both groups completed a 14 weeks high-load resistance training program. Changes in Achilles tendon cross-sectional area, tendon stiffness, muscular strength, and thickness of the plantar flexors were measured. The group that was supplemented with collagen peptides showed a significantly greater increase in tendon cross section area compared with the groups that was given placebo. Moreover, the statistical analysis revealed a significantly greater increase in muscle thickness in the collagen peptides group compared with the placebo group. Finally, tendon stiffness and muscle strength increased in both groups, with no statistical difference between the groups. In conclusion, the current study shows that the supplementation of collagen peptides combined with resistance training is associated with a greater hypertrophy in tendinous and muscular structures than resistance training alone.
The full article can be found here: https://pubmed.ncbi.nlm.nih.gov/35403756/
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E. Proksch, D. Segger, J. Degwert, M. Schunck, V. Zague, S. Oesser; Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study. Skin Pharmacol Physiol 1 August 2013; 27 (1): 47–55.
https://doi.org/10.1159/000351376
Denise Zdzieblik, Steffen Oesser, Albert Gollhofer, and Daniel König. 2017. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Applied Physiology, Nutrition, and Metabolism. 42(6): 588-595. https://doi.org/10.1139/apnm-2016-0390
Zdzieblik, D.; Brame, J.; Oesser, S.; Gollhofer, A.; König, D. The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial. Nutrients 2021, 13, 523. https://doi.org/10.3390/nu13020523
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Doris Hexsel MD, Vivian Zague PhD, Michael Schunck PhD, Carolina Siega BSc, Fernanda O Camozzato MD, Steffen Oesser PhD; First published: 08 August 2017 https://doi.org/10.1111/jocd.12393 Citations: 24
Jendricke, P.; Centner, C.; Zdzieblik, D.; Gollhofer, A.; König, D. Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial. Nutrients 2019, 11, 892. https://doi.org/10.3390/nu11040892
Zdzieblik, D.; Jendricke, P.; Oesser, S.; Gollhofer, A.; König, D. The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained Men: A Randomized Controlled Trial. Int. J. Environ. Res. Public Health 2021, 18, 4837. https://doi.org/10.3390/ijerph18094837
Kirmse, M.; Oertzen-Hagemann, V.; de Marées, M.; Bloch, W.; Platen, P. Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men. Nutrients 2019, 11, 1154. https://doi.org/10.3390/nu11051154
Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. 2015 Oct 28;114(8):1237-45. doi: 10.1017/S0007114515002810. Epub 2015 Sep 10. PMID: 26353786; PMCID: PMC4594048.
Jerger S, Centner C, Lauber B, Seynnes O, Sohnius T, Jendricke P, Oesser S, Gollhofer A, König D. Effects of specific collagen peptide supplementation combined with resistance training on Achilles tendon properties. Scand J Med Sci Sports. 2022 Jul;32(7):1131-1141. doi: 10.1111/sms.14164. Epub 2022 Apr 20. PMID: 35403756.
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Hoppeler H. Molecular networks in skeletal muscle plasticity. J. Exp. Biol. 2016;219:205–213. doi: 10.1242/jeb.128207. - DOI – PubMed
Seong, S. H., Lee, Y. I., Lee, J., Choi, S., Kim, I. A., Suk, J., … & Lee, J. H. (2023). Low‐molecular‐weight collagen peptides supplement promotes a healthy skin: a randomized, double‐blinded, placebo‐controlled study. Journal of Cosmetic Dermatology, 23(2), 554-562. https://doi.org/10.1111/jocd.16026
E. Proksch, D. Segger, J. Degwert, M. Schunck, V. Zague, S. Oesser; Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study. Skin Pharmacol Physiol 1 August 2013; 27 (1): 47–55.
https://doi.org/10.1159/000351376
Denise Zdzieblik, Steffen Oesser, Albert Gollhofer, and Daniel König. 2017. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Applied Physiology, Nutrition, and Metabolism. 42(6): 588-595. https://doi.org/10.1139/apnm-2016-0390
Zdzieblik, D.; Brame, J.; Oesser, S.; Gollhofer, A.; König, D. The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial. Nutrients 2021, 13, 523. https://doi.org/10.3390/nu13020523
Clark, K. L., Sebastianelli, W., Flechsenhar, K. R., Aukermann, D. F., Meza, F., Millard, R. L., … Albert, A. (2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion, 24(5), 1485–1496. https://doi.org/10.1185/030079908X291967
Doris Hexsel MD, Vivian Zague PhD, Michael Schunck PhD, Carolina Siega BSc, Fernanda O Camozzato MD, Steffen Oesser PhD; First published: 08 August 2017 https://doi.org/10.1111/jocd.12393 Citations: 24
Jendricke, P.; Centner, C.; Zdzieblik, D.; Gollhofer, A.; König, D. Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial. Nutrients 2019, 11, 892. https://doi.org/10.3390/nu11040892
Zdzieblik, D.; Jendricke, P.; Oesser, S.; Gollhofer, A.; König, D. The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained Men: A Randomized Controlled Trial. Int. J. Environ. Res. Public Health 2021, 18, 4837. https://doi.org/10.3390/ijerph18094837
Kirmse, M.; Oertzen-Hagemann, V.; de Marées, M.; Bloch, W.; Platen, P. Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men. Nutrients 2019, 11, 1154. https://doi.org/10.3390/nu11051154
Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. 2015 Oct 28;114(8):1237-45. doi: 10.1017/S0007114515002810. Epub 2015 Sep 10. PMID: 26353786; PMCID: PMC4594048.
Jerger S, Centner C, Lauber B, Seynnes O, Sohnius T, Jendricke P, Oesser S, Gollhofer A, König D. Effects of specific collagen peptide supplementation combined with resistance training on Achilles tendon properties. Scand J Med Sci Sports. 2022 Jul;32(7):1131-1141. doi: 10.1111/sms.14164. Epub 2022 Apr 20. PMID: 35403756.
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